The diagnostic accuracy of lung ultrasound to determine PiCCO-derived extravascular lung water in invasively ventilated patients with COVID-19 ARDS

The Ultrasound Journal

Table 3 Diagnostic accuracy of lung ultrasound scores to detect EVLWi > 15 ml/kg

Score	Score cut off	AUROCC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
Global LUS	11	0.73 (0.52–0.94)	0.91 (0.90–0.92)	0.29 (0.14–0.44)	0.50 (0.44–0.56)	0.80 (0.78–0.83)
LUS–ARDS	37	0.85 (0.70–1.00)	0.91 (0.90–0.92)	0.71 (0.67–0.76)	0.64 (0.59–0.69)	0.90 (0.89–0.91)
Anterior–lateral LUS	8	0. 79 (0.58–1.0)	0.91 (0.90–0.92)	0.57 (0.50–0.64)	0.63 (0.57–0.68)	0.89 (0.87–0.90)

Summary of the diagnostic accuracy measures of the 12-region global LUS and LUS–ARDS scores and the reduced 8-region anterior–lateral LUS score to detect severe pulmonary edema (EVLWi > 15 ml/kg) at the respective cutoff values. ARDS Acute Respiratory Distress Syndrome, AUROCC area under the receiver operating curve, EVLWi extravascular lung water index, LUS lung ultrasound, NPV negative predictive value, PPV positive predictive value